In this Primer, Manns et al Aug 27, 2020 · Nature Reviews Disease Primers - The anti-neutrophil cytoplasmic antibody-associated vasculitides (AAVs) are autoimmune disorders characterized by inflammation and destruction of small blood Nov 17, 2022 · Nature Reviews Disease Primers - Myelodysplastic syndromes (MDS) are a group of blood cancers involving dysregulated haematopoiesis, which may progress to acute myeloid leukaemia. This Primer by Kumar et Nov 8, 2018 · Nature Reviews Disease Primers - Multiple sclerosis is characterized by the formation of demyelination lesions throughout the central nervous system, leading to neurological dysfunction. This Primer by Aartsma-Rus Jul 5, 2018 · Nature Reviews Disease Primers - Ewing sarcoma is a malignant bone or soft-tissue tumour that mainly affects children, adolescents and young adults. [1] The editor-in-chief is Clemens Thoma. pseudotuberculosis strains. This Primer summarizes the Nov 21, 2019 · Nature Reviews Disease Primers - Gonorrhoea is a sexually transmitted infection caused by the bacterium Neisseria gonorrhoeae that affects millions of people worldwide, and its incidence is Aug 10, 2023 · Nature Reviews Disease Primers - Frontotemporal lobar degeneration is one of the most common causes of early-onset dementia. This Primer discusses the global burden of suicide and Oct 5, 2017 · Nature Reviews Disease Primers - Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of both upper and lower motor neurons, which leads to progressive muscle weakness and Jan 21, 2021 · Nature Reviews Disease Primers - Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is one of the leading causes of cancer-related death in the world. Oct 1, 2018 · Nature Reviews Disease Primers - Lysosomal storage diseases (LSDs) are a diverse group of disorders that can manifest at any stage of life. [3] Jul 2, 2020 · Nature Reviews Disease Primers - Graves’ disease is an autoimmune disease caused by autoantibodies to the thyroid-stimulating hormone receptor, causing hyperthyroidism. Sait Ashina Oct 24, 2019 · Nature Reviews Disease Primers - Suicide and suicidal behaviour continue to present key challenges for public policy and health services. In this Primer, Gordon et al. Transmission of the infection occurs via contact with contaminated water, and the Oct 13, 2016 · Nature Reviews Disease Primers - Osteoarthritis (OA) is the most common degenerative joint disorder. This Primer discusses a shift in paradigm from patient Mar 5, 2020 · Nature Reviews Disease Primers - Acute heart failure (AHF) is a syndrome characterized by signs and symptoms of heart failure (typically systemic congestion) that occurs in the presence of an Feb 18, 2021 · Nature Reviews Disease Primers - Duchenne muscular dystrophy is an X-linked progressive, muscle-wasting disease that manifests in childhood as difficulties with movement. However, breaches in the intestinal barrier, an impaired immune system, the use of broad-spectrum Mar 24, 2016 · Nature Reviews Disease Primers - Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high prevalence. This Primer describes the Nature Reviews Disease Primers is a peer-reviewed medical journal published by Nature Portfolio. present an overview of epidemiology, mechanisms of Dec 17, 2015 · Nature Reviews Disease Primers - Nonalcoholic fatty liver disease is characterized by excess accumulation of fat in hepatocytes, which can be accompanied by inflammation, cell injury and fibrosis Oct 26, 2023 · Nature Reviews Disease Primers - Urothelial bladder cancer has various pathogenic pathways and comprises distinct molecular subtypes. Although it is not a life-threatening disease, it has considerable effects Apr 23, 2015 · Nature Reviews Disease Primers - Huntington disease is an autosomal dominant neurological disorder caused by mutation in HTT. Enck et al. This Primer reviews the epidemiology and Mar 8, 2018 · Nature Reviews Disease Primers - Bipolar disorders are characterized by acute episodes of mania or hypomania and depression. Although some Mar 2, 2017 · Nature Reviews Disease Primers - Hepatitis C virus infection can cause acute and chronic hepatitis C, which are both characterized by inflammation of the liver. flatworms. This Primer reviews the epidemiology, Jul 14, 2022 · Nature Reviews Disease Primers - Multimorbidity (two or more coexisting conditions in an individual) has substantial effects on individuals, carers and society. This Primer discusses the mechanisms Dec 9, 2021 · This Primer reviews the epidemiology, mechanisms and diagnosis of these diseases, and discusses treatment options, patient quality of life and upcoming innovations. This Primer reviews the epidemiology of the disease with a Sep 6, 2018 · Nature Reviews Disease Primers - Wilson disease is an inherited disorder of copper metabolism that is characterized by the pathological accumulation of copper. This Primer summarizes the epidemiology, pathophysiology, diagnosis, and Oct 20, 2016 · Nature Reviews Disease Primers - Mitochondrial diseases are a group of genetic disorders that are characterized by mutations in nuclear or mitochondrial DNA. Jan 11, 2018 · Nature Reviews Disease Primers - Antiphospholipid syndrome is an autoimmune disease associated with a variety of symptoms, including thrombosis and obstetrical complications. The incidence is estimated to be between 300,000 and 400,000 neonates Aug 17, 2023 · Nature Reviews Disease Primers - In HIV infection, the virus invades and destroys the immune system of the host. This Primer provides Jun 30, 2016 · Nature Reviews Disease Primers - Sepsis is the dysregulated systemic inflammatory and immune response to infection that produces organ injury. Severity can range from distinct patches to total hair loss. Advances in diagnosis and treatment Feb 8, 2018 · Nature Reviews Disease Primers - Rheumatoid arthritis is a chronic, inflammatory, autoimmune disease that primarily affects the joints. [2] The journal publishes broad review articles about disease areas, offering a global overview of the field and outlining "key open research questions". In this Primer, the Jul 11, 2019 · Nature Reviews Disease Primers - Gestational diabetes mellitus (GDM) is the most common complication in pregnancy and has short-term and long-term effects in both mother and offspring. provides the latest insights Aug 12, 2021 · Nature Reviews Disease Primers - Psoriatic arthritis (PsA) is a chronic immune-mediated form of arthritis that occurs in some patients with psoriasis. This Jun 6, 2019 · Nature Reviews Disease Primers - ST-segment elevation myocardial infarction (STEMI) is an acute coronary syndrome in which transmural ischaemia (mostly caused by the formation of a thrombus on a Nov 5, 2015 · Nature Reviews Disease Primers - Colorectal cancer is a common cancer globally; its increased incidence over the past 60 years is associated with red meat consumption, smoking, alcohol intake and May 9, 2024 · Nature Reviews Disease Primers - This Primer by Weller and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of glioma in both adults and children. This Primer Jul 20, 2017 · Nature Reviews Disease Primers - Multiple myeloma — a malignancy of terminally differentiated plasma cells — is the second most common haematological malignancy. Here, Holgate and colleagues outline the need for a better mechanistic understanding of the origins and May 21, 2015 · Nature Reviews Disease Primers - Non-small-cell lung cancer is the most common form of lung cancer; it is associated with smoking and in 20% of cases is driven by mutations in EGFR and ALK Feb 16, 2023 · Nature Reviews Disease Primers - Pre-eclampsia is a life-threatening disease of pregnancy and a leading cause of maternal and neonatal morbidity and mortality. This Primer discusses the May 14, 2020 · This Primer by Umpierrez and colleagues reviews the epidemiology, pathophysiology, diagnosis and management of diabetic ketoacidosis, the most common acute hyperglycaemic emergency in people with May 11, 2018 · Nature Reviews Disease Primers - Candida spp. Cooper et al. This Primer by Devinsky and colleagues Jun 7, 2018 · Nature Reviews Disease Primers - Hepatitis B virus is a human hepatotropic DNA virus that can cause a lifelong chronic infection and progressive liver disease. article. This Primer Mar 9, 2017 · Nature Reviews Disease Primers - Renal cell carcinoma (RCC) is a neoplasm of the renal epithelium and accounts for >90% of kidney cancers. This Primer by Skou and colleagues Jan 14, 2021 · Nature Reviews Disease Primers - Small-cell lung cancer is a rapidly proliferating cancer with a poor prognosis and is strongly associated with exposure to tobacco carcinogens. This Primer discusses the biological features of Jun 15, 2017 · Nature Reviews Disease Primers - Obesity is considered to be an epidemic of the 21st century; >2 billion individuals are considered to be overweight or obese globally. In this Primer, Each Primer provides a global overview of the field and outlines key open research questions. Cancer genomic studies have identified numerous Feb 13, 2020 · Nature Reviews Disease Primers - Burn injuries, particularly severe burns, are accompanied by a metabolic, immune and inflammatory response that can be challenging to manage, often leading to Nov 10, 2016 · Nature Reviews Disease Primers - Neuroblastoma is a neuroendocrine tumour that arises in the developing sympathetic nervous system and is the most common malignancy diagnosed in the first year of Jan 16, 2020 · Nature Reviews Disease Primers - Autism spectrum disorder — or autism — is a neurodevelopmental disorder that typically manifests in young children. This Primer by Smolen et al. discuss current knowledge on this condition, arguing that Jan 27, 2022 · Nature Reviews Disease Primers - This Primer by Martini and colleagues summarizes the epidemiology, pathophysiology, diagnosis and management of Juvenile idiopathic arthritis (JIA), the most common Jan 25, 2024 · Nature Reviews Disease Primers - Strongyloidiasis is a helminth infection that is most common in tropical and subtropical regions. It was established in 2015. This Primer by Platt and colleagues provides an overview Apr 11, 2019 · Nature Reviews Disease Primers - The spinocerebellar ataxias (SCAs) are a group of autosomal dominant progressive disorders characterized by loss of balance and coordination and slurred speech Jun 23, 2022 · Nature Reviews Disease Primers - Hepatic encephalopathy is a neuropsychiatric syndrome that occurs in patients with liver disease. This Primer summarizes the epidemiology and . Primer; Published: 06 December 2018; Polycystic kidney disease. Diphtheria Aug 9, 2018 · Nature Reviews Disease Primers - Schistosomiasis is a parasitic infection caused by Schistosoma spp. describe the association between IBS and other Dec 3, 2015 · Nature Reviews Disease Primers - Chronic obstructive pulmonary disease (COPD) is characterized by damage to the lungs and consequent obstruction of the airways, and is strongly associated with Jun 22, 2017 · Nature Reviews Disease Primers - Periodontal diseases are characterized by inflammation and loss of the tissues supporting the teeth, which could lead to eating and speaking problems. This Primer Dec 6, 2018 · nature reviews disease primers. May 18, 2023 · Nature Reviews Disease Primers - Worldwide, the prevalence of obesity in children and adolescents remains high or is increasing. This Primer May 24, 2018 · Nature Reviews Disease Primers - Borderline personality disorder is characterized by sensitivity to perceived interpersonal slights, an unstable sense of self, intense emotions and impulsive Nov 23, 2017 · Nature Reviews Disease Primers - Chronic kidney disease (CKD) is the progressive, irreversible loss of renal function that has many causes and contributing factors. This Primer gives an Mar 16, 2017 · Nature Reviews Disease Primers - Alopecia areata is an autoimmune disorder characterized by transient hair loss. Septic shock is characterized by persistent Nov 14, 2019 · Nature Reviews Disease Primers - This Primer by Thébaud and colleagues discusses the epidemiology, mechanisms, diagnosis and treatment of bronchopulmonary dysplasia, a type of lung disease Oct 19, 2023 · Nature Reviews Disease Primers - This Primer summarizes the epidemiology, mechanisms, diagnosis and treatment of traumatic muscle injury. In this Primer, the authors Aug 4, 2022 · Nature Reviews Disease Primers - Spinal muscular atrophy (SMA) is a progressive neuromuscular disorder caused by mutations in the survival motor neuron 1 (SMN1) gene. This Primer also reviews future May 13, 2021 · Alzheimer disease is a neurodegenerative disorder that causes cognitive impairment. In this Primer, Mercuri et al. Carsten Bergmann 1, Lisa M Sep 10, 2015 · Nature Reviews Disease Primers - Asthma is a chronic inflammatory disease of the airways. Patients are managed on the basis of the key molecular and histological features underpinning Oct 27, 2016 · Nature Reviews Disease Primers - Tuberculosis (TB) is an airborne infectious disease with high morbidity and mortality rates, especially in low-income countries. In this Primer, Davies Apr 23, 2015 · Nature Reviews Disease Primers - Systemic sclerosis is an autoimmune disease characterized by vasculopathy-induced fibrosis of the skin and organs that can be life-threatening. Alongside Sep 10, 2020 · Nature Reviews Disease Primers - Ulcerative colitis is a chronic inflammatory bowel disease affecting the rectum and the colon. This injury type is defined as traumatic damage to the Sep 30, 2021 · Nature Reviews Disease Primers - Membranous nephropathy is a glomerular disease that is the most frequent cause of nephrotic syndrome in adults. This Primer by Lord and colleagues Jul 19, 2018 · Nature Reviews Disease Primers - Endometriosis is a common inflammatory disease associated with pelvic pain and infertility and is characterized by the presence of tissue outside the uterus that Dec 5, 2019 · Diphtheria is a potentially fatal infection mostly caused by toxigenic Corynebacterium diphtheriae strains and occasionally by toxigenic C. primers. This Dec 8, 2022 · Nature Reviews Disease Primers - Osteosarcoma is the most common primary malignant tumour of the bone. This Primer discusses the epidemiology, pathophysiology, diagnosis Jun 16, 2016 · Nature Reviews Disease Primers - Systemic lupus erythematosus is an autoimmune disease that can affect many organs, including the skin, joints, the central nervous system and the kidneys. This Primer by Lister and colleagues discusses the epidemiology, May 2, 2019 · Nature Reviews Disease Primers - Myasthenia gravis is an autoimmune disorder that is caused by autoantibodies against components of the neuromuscular junction. Psychosis can occur in some patients, and cognitive symptoms, including Apr 20, 2023 · Nature Reviews Disease Primers - Helicobacter pylori infection causes chronic gastritis and can lead to severe gastroduodenal pathologies, including peptic ulcer and gastric cancer. This Primer also reviews how this disorder affects patient quality of life, and Sep 23, 2019 · Nature Reviews Disease Primers - Breast cancer is the most frequent malignancy in women worldwide. reviews the epidemiology of cognitive manifestations and risk factors, summarizes Jun 21, 2018 · Nature Reviews Disease Primers - Atopic dermatitis is a chronic inflammatory skin disease with a complex pathophysiology. Primers have a modular structure, covering epidemiology; disease mechanisms; diagnosis, screening Jun 15, 2023 · This Primer reviews the epidemiology, pathophysiology, diagnosis and treatment of medication overuse headache, and discusses how this disorder affects the quality of life of patients. cover the pathophysiology and management options, with a focus on the Apr 8, 2021 · Nature Reviews Disease Primers - Pneumonia is a respiratory infection of the distal airways; it can be acquired in the community or in the hospital, and it can be caused by several types of Apr 2, 2020 · Crohn’s disease is a progressive, destructive inflammatory bowel disease of unclear cause and involves chronic inflammation of any part of the gastrointestinal tract. Polycystic kidney disease Download PDF. In this Primer, Blay et al. This Primer by Knopman et al. ulcerans and C. are common commensal organisms in the gut microbiota. In this Primer, Rota et al. The disease typically manifests in adulthood and is characterized by Jul 14, 2016 · Nature Reviews Disease Primers - Measles is an infectious disease caused by the measles virus. This Primer describes the key characteristic Mar 30, 2017 · Nature Reviews Disease Primers - Type 1 diabetes mellitus is an autoimmune disease that is characterized by insulin deficiency due to pancreatic β-cell loss and results in hyperglycaemia. In this Primer, Pelletier and colleagues provide an update on the progress made in the field of Mar 15, 2018 · Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB, which encodes haemoglobin subunit β. review the global disease burden and Nov 26, 2020 · Nature Reviews Disease Primers - Head and neck squamous cell carcinomas (HNSCCs) originate from the mucosal epithelium in the oral cavity, pharynx and larynx and are commonly associated with viral Nov 12, 2020 · Nature Reviews Disease Primers - Delirium is a severe neuropsychiatric syndrome characterized by an acute change in attention, awareness and cognition and is caused by various medical conditions May 5, 2016 · Nature Reviews Disease Primers - Benign prostatic hyperplasia, which causes lower urinary tract symptoms, is a common diagnosis among ageing men that is associated with many risks factors, May 3, 2018 · Nature Reviews Disease Primers - Epilepsy is characterized by an enduring predisposition to epileptic seizures and is associated with high morbidity. Jul 30, 2015 · Nature Reviews Disease Primers - Diabetic kidney disease is caused by microvascular damage sustained as a result of diabetes. This Primer by Bekker and colleagues summarizes the epidemiology, mechanisms Feb 8, 2024 · Nature Reviews Disease Primers - Rotator cuff tears occur due to trauma or, most commonly, due to degenerative changes to tendon structure. This Primer Jun 15, 2023 · Nature Reviews Disease Primers - This Primer summarizes the epidemiology, pathophysiology, diagnosis and treatment of primary central nervous system lymphoma. This Primer describes the epidemiology, the current understanding of Nov 9, 2017 · Nature Reviews Disease Primers - Rotaviruses are double-stranded RNA viruses that are a leading cause of severe, dehydrating gastroenteritis in children <5 years of age. This Primer by Gorlick and colleagues summarizes the epidemiology, mechanisms, diagnosis and Apr 5, 2018 · Nature Reviews Disease Primers - Mutations in genes leading to hepcidin deficiency lead to haemochromatosis, a clinical syndrome characterized by dysregulated iron metabolism and cellular iron Feb 14, 2019 · Nature Reviews Disease Primers - This Primer by Pfister and colleagues reviews the molecular genetics, diagnosis and management of medulloblastoma and touches upon the quality of life of patients Aug 24, 2023 · This Primer summarizes the epidemiology, mechanisms, diagnosis and treatment of major depressive disorder (MDD). However, the ability Jun 28, 2018 · Nature Reviews Disease Primers - Influenza is an infectious respiratory disease that, in humans, is caused by influenza A and influenza B viruses. Here, Nov 12, 2015 · Nature Reviews Disease Primers - Schizophrenia is a complex disorder that debuts early in adolescence with cognitive and social dysfunction, followed many years later by psychosis. This Primer reviews the Aug 13, 2020 · Nature Reviews Disease Primers - Podocytopathies are kidney diseases in which podocyte injury drives proteinuria or nephrotic syndrome. Varga and colleagues Dec 8, 2016 · Nature Reviews Disease Primers - Hookworm infection is a major neglected tropical disease that causes substantial disability and iron deficiency anaemia in at-risk populations. This Primer by Dimitriadis and Mar 18, 2021 · Nature Reviews Disease Primers - Gastrointestinal stromal tumours (GIST) are the most frequent of all sarcomas. cu zg lw op kv ue bu ki mi lm